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KMID : 0980720110300010053
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Keimyung Medical Journal
2011 Volume.30 No. 1 p.53 ~ p.60
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The Comparison of Efficacy Between Concurrent Chemoradiotherapy and Hepatic Arterial Infusion Therapy in Hepatocellular Carcinoma
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Kim Tae-Yul
Hwang Jae-Seok
Cho Kwang-Bum
Park Kyung-Sik
Chung Woo-Jin
Jang Byoung-Kuk
Kim Eun-Soo
Lee Kyung-In
Lee Sun-Young
Choi Jae-Hyuk
Choi Jong-Hwan
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Abstract
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Background/Aims : Patients with advanced hepatocellular carcinoma showed a poor prognosis and there is no curative therapy. The aim of this study was to compare the therapeutic efficacy of concurrent chemoradiotherapy (CCRT) and hepatic arterial infusion therapy (HAIT) in advanced HCC.
Methods: Between April 2004 and April 2009, thirty four patients (CCRT; 15 and HAIT; 19) with advanced HCC (BCLC stage C) were included in this study. The patients received 5-FU (250 mg)/ Cisplatin 10 mg)/leucovorin (12 mg) for 5 days every 3 weeks via implanted chemoport. In CCRT group, patients were treated with external beam radiotherapy (4500 cGy/5 weeks) in addition to HAIT. After 2 cycles of all these therapies, abdominal CT and serum α-FP were checked to evaluate therapeutic efficacies.
Results: In patients treated with CCRT or HAIT, response rates after 2 cycles were 73.3% (PR 11, SD 2, PD 2) vs 10.5% (PR 2, SD 9, PD 8), respectively (p=0.001). The median survival time of CCRT group was 142 days compared with
166 days for HAIT (p=0.577).
Conclusions: CCRT can achieves more favorable results in advanced HCC with good reserve liver function compared with HAIT but there was no differences in median survival times between two groups, Thus further investigation is required to assess long term response rate and overall survival.
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KEYWORD
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Carcinoma, Concurrent chemoradiotherapy, Hepatic arterial infusion therapy, Hepatocellular
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